What is pemetrexed?
Pemetrexed is used to treat non-small cell lung cancerafter other cancer medications have been tried without successful treatment.
Pemetrexed may also be used for purposes not listed in this medication guide.
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
Before taking this medicine
You should not receive this medication if you are allergic to pemetrexed.
To make sure pemetrexed is safe for you, tell your doctor if you have:
- kidney disease (especially if you take ibuprofen (Advil, Motrin) or other nonsteroidal anti-inflammatory drugs, or NSAIDs);
- liver disease;
- a weak immune system; or
- excess fluid in the space around your lung, liver, or other internal organs, including pleural effusion(fluid around the lungs) or ascites (fluid around the liver).
Do not use pemetrexed if you are pregnant. It could harm the unborn baby. Use effective birth control to avoid pregnancy during your treatment with pemetrexed. Follow your doctor’s instructions about how long to prevent pregnancy after your treatment ends.
It is not known whether pemetrexed passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using pemetrexed.
How is pemetrexed given?
Pemetrexed is injected into a vein through an IV. A healthcare provider will give you this injection.
Pemetrexed is usually given every 3 weeks. Your doctor will determine how many treatment cycles you should receive.
To prevent certain side effects of pemetrexed, you will need to take folic acid supplements and receive vitamin B12 injections (starting 7 days before your first dose of pemetrexed). Take only the amount of folic acid that your doctor has prescribed.
Your doctor may also prescribe steroid medication to reduce certain side effects of pemetrexed. Follow your doctor’s dosing instructions very carefully.
Pemetrexed can lower blood cells that help your body fight infections and help your blood to clot. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results of these tests.
What happens if I miss a dose?
Call your doctor for instructions if you miss an appointment for your pemetrexed injection.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while receiving pemetrexed?
Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.
Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.
Do not receive a “live” vaccine while using pemetrexed, and avoid coming into contact with anyone who has recently received a live vaccine. There is a chance that the virus could be passed on to you. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.
This medicine can pass into body fluids (urine, feces, vomit). For at least 48 hours after you receive a dose, avoid allowing your body fluids to come into contact with your hands or other surfaces. Caregivers should wear rubber gloves while cleaning up a patient’s body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.
Pemetrexed side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
- severe ongoing vomiting or diarrhea;
- bone marrow suppression–fever, swollen gums, painful mouth sores, cold or flu symptoms, sore throat, pale skin, easy bruising or bleeding, skin sores, red or pink urine, rapid heart rate, feeling light-headed or short of breath,
- kidney problems–swelling, rapid weight gain, little or no urinating;
- signs of dehydration–feeling very thirsty or hot, being unable to urinate, heavy sweating, hot and dry skin; or
- severe skin reaction–fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
Common side effects may include:
- tired feeling, loss of appetite, weight loss;
- upset stomach, nausea, vomiting, diarrhea;
- mild rash; or
- hair loss.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect pemetrexed?
Pemetrexed can harm your kidneys. This effect is increased when you also use certain other medicines, including: antivirals, chemotherapy, injected antibiotics, medicine for bowel disorders, medicine to prevent organ transplant rejection, injectable osteoporosis medication, and some pain or arthritis medicines (including aspirin, Tylenol, Advil, and Aleve).
This list is not complete. Other drugs may interact with pemetrexed, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Follow the following prescription medicine precautions :
|Pemnat 100mg may be harmful for your baby during pregnancy. Take proper medical help in case you are pregnant, may be pregnant or planning to become pregnant in the near future.|
|This medicine is not indicated for use in women. It is not known if Pemetrexed is excreted in human milk. Because of the potential for serious adverse reactions in nursing infants from Pemnat, a decision should be made to either discontinue nursing, or discontinue the drug taking into account the importance of the drug to the mother.|
|Your health care professional can check blood tests to regularly monitor your liver and kidney function, while you are taking Pemnat. It is also important to check your levels of blood cells and other substances in the blood.|
|Before taking this medicine, tell your doctor and pharmacist if you are allergic to Pemetrexed, any other medications, or any of the ingredients in Pemetrexed medicine. This medication is not recommended for use in patients with a known allergy to Pemnat (Pemetrexed) 100 mg.|
|If you take Pemnat, you must stop drinking alcohol. This is one of the ways to prevent this disease from getting worse. If you are dependent on alcohol and want to stop drinking, your doctor can recommend a therapy that’s tailored for your needs.|
|If you use other prescription drugs or over the counter products at the same time, the effects of this cancer medicine may change. Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that your pharmacist can help you prevent or manage drug interactions.|
|Missing a dose of Pemnat can upset your treatment plan. If you do miss one of your doses, take it as soon as you remember, unless it’s almost time to take your next dose. In this case, you should just skip the missed dose. Don’t take a double dose to “make up” for the one you missed. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.|
|Do not take Pemetrexed the use by (expiry) date printed on the pack. Do not take it if the packaging is torn or shows signs of tampering. If it has expired or is damaged, return it to your pharmacist for disposal.|
|During your treatment with Pemnat, it is very important for your doctor to know about your medical history if you have Kidney problems, hepatitis, liver problems, HIV (human immunodeficiency virus), triglycerides, diabetes or other health problems.|
What are the storage instructions for Pemnat 100 mg ?
Patients must properly store the drug to retain its quality and efficacy. Following storage instructions will be helpful in storing the drug in the best of manner.
- Store intact vials at room temperature of 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). Reconstituted solution and infusion solution are stable for 24 hours when refrigerated at 2°C to 8°C (36°F to 46°F).
• When you aren’t injecting, store Pemnat Pre-filled syringes in a place that’s protected from light.
• Make sure to always keep your medicine in an area of your home that is out of the reach of children and pets.
• Do not use Pemetrexed if the liquid in the vial looks discolored or cloudy, or if the liquid has lumps, flakes, or particles.
• Do not freeze Pemnat.
In order to legally purchase this medicine from DrugsSquare, you’ll require a prescription from your Registered Medical Practitioner.
The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.
Remember, keep this and all other medicines out of the reach of children and away from pets, never share your medicines with others, and use this medication only for the indication prescribed.
The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.