What is Febustat febuxostat?
Febuxostat is used to keep uric acid levels from getting to high in people with gout.
Febuxostat may also be used for purposes not listed in this medication guide.
Before taking this medicine
You should not use febuxostat if you are allergic to it, or if you also use:
- azathioprine; or
Tell your doctor if you have ever had:
- liver or kidney disease;
- heart disease;
- a heart attack or stroke;
- Lesch-Nyhan syndrome; or
- an organ transplant (kidney, liver, lung, heart).
It is not known whether febuxostat will harm an unborn baby. Tell your doctor if you are pregnant or plan.
It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.
How should I take febuxostat?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
You may take febuxostat with or without food. Febuxostat may be taken with an antacid if needed.
You may have an increase in gout symptoms (flares) when you first start taking febuxostat. Your doctor may prescribe other medications for you to use during the first 6 months of treatment with febuxostat.
For best results, keep using your medications as directed. Call your doctor if your symptoms do not improve after 6 months, or if they get worse.
You will need frequent blood tests to check your liver function.
Store at room temperature away from moisture, heat, and light.
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking febuxostat?
Follow your doctor’s instructions about any restrictions on food, beverages, or activity.
Febuxostat side effects
Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).
Seek medical treatment if you have a serious drug reaction that can affect many parts of your body.Symptoms may include: skin rash, fever, swollen glands, flu-like symptoms, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.
Call your doctor at once if you have:
- heart attack symptoms–chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;
- liver problems–stomach pain (upper right side), unusual tiredness, dark urine, jaundice (yellowing of the skin or eyes); or
- signs of a stroke–sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance.
Common side effects may include:
- gout flares, joint pain;
- mild rash; or
- liver problems.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
Febuxostat dosing information
Usual Adult Dose for Gout:
Initial dose: 40 mg orally once a day
-If serum uric acid level is greater than 6 mg/dL after 2 weeks, increase the dose to 80 mg orally once a day
Maintenance dose: 40 to 80 mg orally once a day
-Use of this drug should occur after an acute gout flare subsides.
-Gout flares may occur due to increased urate mobilization from tissue deposits, especially during initiation; gout flare prophylaxis with a non-steroidal anti-inflammatory or colchicine is recommended and may be beneficial for up to 6 months.
-Uric acid levels may be checked as soon as 2 weeks after beginning this drug.
Use: Chronic management of symptomatic hyperuricemia in patients with gout
What other drugs will affect febuxostat?
Tell your doctor about all your other medicines, especially:
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Follow the following prescription medicine precautions :
|Febuxostat may be harmful for your baby during pregnancy. Take proper medical help in case you are pregnant, may be pregnant or planning to become pregnant in the near future.
|This medicine is not indicated for use in women. It is not known if Febuxostat is excreted in human milk. Because of the potential for serious adverse reactions in nursing infants from Febuxostat a decision should be made to either discontinue nursing, or discontinue the drug taking into account the importance of the drug to the mother.
|Your health care professional can check blood tests to regularly monitor your liver and kidney function, while you are taking Febuxostat. It is also important to check your levels of blood cells and other substances in the blood.
|Before taking this medicine, tell your doctor and pharmacist if you are allergic to Letrodex, any other medications, or any of the ingredients in Febuxostat medicine. This medication is not recommended for use in patients with a known allergy to Febuxostat.
|If you take Febuxostat, you must stop drinking alcohol. This is one of the ways to prevent this disease from getting worse. If you are dependent on alcohol and want to stop drinking, your doctor can recommend a therapy that’s tailored for your needs.
|If you use other prescription drugs or over the counter products at the same time, the effects of this cancer medicine may change. Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that your pharmacist can help you prevent or manage drug interactions.
|Missing a dose of Febuxostat can upset your treatment plan. If you do miss one of your doses, take it as soon as you remember, unless it’s almost time to take your next dose. In this case, you should just skip the missed dose. Don’t take a double dose to “make up” for the one you missed. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
|Do not take Febuxostat the use by (expiry) date printed on the pack. Do not take it if the packaging is torn or shows signs of tampering. If it has expired or is damaged, return it to your pharmacist for disposal.
|During your treatment with Febuxostat, it is very important for your doctor to know about your medical history if you have Kidney problems, hepatitis, liver problems, HIV (human immunodeficiency virus), triglycerides, diabetes or other health problems.
What are the storage instructions for Febuxostat ?
Patients must properly store the drug to retain its quality and efficacy. Following storage instructions will be helpful in storing the drug in the best of manner.
- Store Febuxostat at room temperature of 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F).
- Make sure to always keep your medicine in an area of your home that is out of the reach of children and pets.
- Do not freeze Febuxostat.
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The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.
Remember, keep this and all other medicines out of the reach of children and away from pets, never share your medicines with others, and use this medication only for the indication prescribed.
The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.