Iclusig 45mg ponatinib

Original price was: $3,500.00.Current price is: $1,600.00.

Brand Name : Iclusig  
Composition : Ponatinib 
Manufactured by : Incyte Pharma Ltd.
Strength : 45 mg
Form :  Tablets
Packing : Pack of 30 Tablets


Prescription Required *

SKU: ICLUSIG45 Category: Tag:


Buy Iclusig 45mg x 30 Tablets of ponatinib At

What is Iclusig?

Iclusig (ponatinib) is a cancer medicine that interferes with the growth of some cancer cells.

Iclusig is used to treat a type of blood cancer called chronic myeloid leukemia (CML), or Philadelphia chromosome positive acute lymphoblastic leukemia (ALL).

Iclusig is usually given after other similar medications have been tried without success.

Important information

Iclusig may cause heart or blood vessel problems that could lead to heart attack or stroke.

Call your doctor or get emergency medical help if you have: chest pain spreading to your jaw or shoulder, shortness of breath, dizziness, severe stomach pain, swelling in your legs, sudden numbness or weakness, headache, or problems with vision or speech.

Iclusig may also harm your liver. Call your doctor right away if you have upper stomach pain with loss of appetite, dark urine, or jaundice (yellowing of the skin or eyes).

Before taking this medicine

You should not use Iclusig if you are allergic to ponatinib.

To make sure Iclusig is safe for you, tell your doctor if you have:

  • heart disease, high blood pressure, heart rhythm problems;
  • a history of stroke or blood clot;
  • diabetes;
  • a history of high cholesterol;
  • liver disease;
  • a bleeding or blood-clotting disorder;
  • a history of pancreatitis;
  • a history of stomach or intestinal bleeding; or
  • lactose intolerance (tablets may contain lactose).

Using Iclusig during pregnancy could harm the unborn baby. Tell your doctor if you are pregnant or if you become pregnant while using this medicine. Use effective birth control to prevent pregnancy during treatment with Iclusig.

It is not known whether ponatinib passes into breast milk or if it could harm a nursing baby. Do not breast-feed while using Iclusig and for at least 6 days after your last dose.

Iclusig is not approved for use by anyone younger than 18 years old.

How should I take Iclusig?

Iclusig is usually taken once daily. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Do not crush, break, or dissolve a Iclusig tablet. Swallow it whole.

You may take Iclusig with or without food.

You may need frequent medical tests to be sure this medication is not causing harmful effects. Your cancer treatments may be delayed based on the results of these tests.

If you need surgery, tell the surgeon ahead of time that you are using Iclusig. You may need to stop using the medicine at least 1 week before a surgery.

Do not stop taking Iclusig or change your medication dose without your doctor’s advice.

Store at room temperature away from moisture and heat.

Iclusig dosing information

Usual Adult Dose for Chronic Myelogenous Leukemia:

45 mg orally once daily

-Iclusig may be taken with or without food and tablets should be swallowed whole.
-59% of patients required dose reductions to 30 mg or 15 mg once daily during the course of therapy.
-Consider reducing the dose for CP CML and AP CML patients who have achieved a major cytogenetic response.
-Consider discontinuing therapy if response has not occurred by 3 months (90 days).

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Iclusig?

This medicine can pass into body fluids (urine, feces, vomit). Caregivers should wear rubber gloves while cleaning up a patient’s body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.

Grapefruit and grapefruit juice may interact with ponatinib and lead to unwanted side effects.

Avoid drinking grapefruit juice while taking this medication.

Iclusig side effects

Get emergency medical help if you have signs of an allergic reaction to Iclusig: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Iclusig may cause heart or blood vessel problems that could lead to heart attack or stroke. Call your doctor right away or get emergency medical help if you have:

  • heart attack symptoms – chest pain or pressure, pain spreading to your jaw or shoulder, feeling short of breath;
  • signs of a stroke – sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance; or
  • signs of a blood clot – severe stomach pain, pain or swelling in your arms or legs, coughing up blood.

Call your doctor at once if you have:

  • headache, confusion, change in mental status, vision loss, seizure (convulsions);
  • severe stomach pain or swelling;
  • fever, flu symptoms;
  • effects on your eyes – eye pain or itching, swollen eyes, dry eyes, bleeding in the eye, increased sensitivity to light, seeing flashes of light or “floaters” in your vision;
  • nerve problems – muscle weakness, trouble moving your eyes or other parts of your face, double vision, altered sense of taste, numbness, tingling, or burning pain in your hands or feet;
  • dangerously high blood pressure – severe headache, blurred vision, pounding in your neck or ears, severe chest pain, shortness of breath;
  • fluid retention – cough, shortness of breath, swelling, rapid weight gain;
  • pancreas problems – severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate;
  • severe bleeding – nosebleeds, bloody or tarry stools, pink or brown urine, heavy menstrual periods, vomit that is bloody or looks like coffee grounds; or
  • signs of tumor cell breakdown – lower back pain, blood in your urine, little or no urination; numbness or tingly feeling around your mouth; muscle weakness or tightness; fast or slow heart rate, weak pulse, feeling short of breath; confusion, fainting.

Common Iclusig side effects may include:

  • dry skin, mild skin rash;
  • stomach pain, nausea, vomiting, diarrhea, constipation;
  • headache, muscle or joint pain;
  • pain in your arms, hands, legs, or feet;
  • increased blood pressure; or
  • fever, tired feeling.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Iclusig?

Tell your doctor about all your current medicines and any you start or stop using, especially:

  • imatinib;
  • nefazodone;
  • St. John’s wort;
  • an antibiotic – clarithromycin, telithromycin;
  • antifungal medicine – itraconazole, ketoconazole, posaconazole, voriconazole;
  • heart or blood pressure medicine – nicardipine, quinidine;
  • antiviral medicine to treat hepatitis or HIV/AIDS – atazanavir, boceprevir, cobicistat, delavirdine, efavirenz, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir, telaprevir;
  • seizure medicine – carbamazepine, phenytoin; or
  • tuberculosis medicine – isoniazid, rifampin.

This list is not complete. Other drugs may interact with ponatinib, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.


Follow the following prescription medicine precautions :

  Iclusig may be harmful for your baby during pregnancy. Take proper medical help in case you are pregnant, may be pregnant or planning to become pregnant in the near future.
  This medicine is not indicated for use in women. It is not known if Iclusig is excreted in human milk. Because of the potential for serious adverse reactions in nursing infants from Iclusig a decision should be made to either discontinue nursing, or discontinue the drug taking into account the importance of the drug to the mother.
  Your health care professional can check blood tests to regularly monitor your liver and kidney function, while you are taking Iclusig . It is also important to check your levels of blood cells and other substances in the blood.
  Before taking this medicine, tell your doctor and pharmacist if you are allergic to Iclusig , any other medications, or any of the ingredients in Iclusig medicine. This medication is not recommended for use in patients with a known allergy to Iclusig .
  If you take Iclusig, you must stop drinking alcohol. This is one of the ways to prevent this disease from getting worse. If you are dependent on alcohol and want to stop drinking, your doctor can recommend a therapy that’s tailored for your needs.
  If you use other prescription drugs or over the counter products at the same time, the effects of this cancer medicine may change. Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that your pharmacist can help you prevent or manage drug interactions.
  Missing a dose of Iclusig can upset your treatment plan. If you do miss one of your doses, take it as soon as you remember, unless it’s almost time to take your next dose. In this case, you should just skip the missed dose. Don’t take a double dose to “make up” for the one you missed. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
  Do not take Iclusig the use by (expiry) date printed on the pack. Do not take it if the packaging is torn or shows signs of tampering. If it has expired or is damaged, return it to your pharmacist for disposal.
  During your treatment with Iclusig, it is very important for your doctor to know about your medical history if you have Kidney problems, hepatitis, liver problems, HIV (human immunodeficiency virus), triglycerides, diabetes or other health problems.


What are the storage instructions for Iclusig ?

Patients must properly store the drug to retain its quality and efficacy. Following storage instructions will be helpful in storing the drug in the best of manner.

  • Store Iclusig at room temperature of 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). 
  • Make sure to always keep your medicine in an area of your home that is out of the reach of children and pets.
  • Do not freeze Iclusig .

Prescription Required:

We Ship in – USA, UK, China, Canada, Russia, Australia, UAE, Singapore, Philippines, Bulgaria, Hungary, Italy, Kenya, Nigeria, Saudi Arabia, Taiwan, Zimbabwe, Malaysia, Spain, Hong Kong and other countries.

In order to legally purchase this medicine from, you’ll require a prescription from your Registered Medical Practitioner.


The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.
Remember, keep this and all other medicines out of the reach of children and away from pets, never share your medicines with others, and use this medication only for the indication prescribed.
The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.


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